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SM22α基因与肿瘤的关系研究进展 被引量：2

Research progress on relationship between SM22α gene and tumor
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摘要 SM22α是一种重要的细胞骨架相关蛋白，近年来发现它在细胞转化、分裂、黏附、转移中都发挥了重要作用。研究表明它在乳腺癌、大肠癌、前列腺癌以及非小细胞肺癌等肿瘤中表达均下调甚至消失。由此推测，SM22α是一种新的肿瘤抑制因子，对它的进一步研究将有助于肿瘤的早期诊断。 SM22α is an important cytoskeletal protein. In recent years, it is found that it plays an important role in cell transformation, division, adhesion and metastasis. Studies have shown that SM22α expression decreases in breast cancer, colon cancer, prostate cancer and non-small cell lung cancer. These results show that SM22α may be a new tumor suppressor, and further researches about SM22α will be helpful for the early diagnosis of tumor.
作者 苏稼航 马卫霞 张群成 伊洪莉 姜淑娟
机构地区 烟台市中医医院药剂科 山东大学附属省立医院呼吸科
出处 《国际呼吸杂志》 2011年第4期287-290,共4页 International Journal of Respiration
关键词 SM22α基因 肿瘤 肿瘤发生 SM22α gene Tumor Tumorigenesis
分类号 R730.4 [医药卫生—肿瘤]
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参考文献19

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同被引文献60

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  • 6Morgan KG, Gangopadhyay SS. Invited review~ cross-bridge regulation by thin filament-associated proteins FJ]. J Appl Phys- iol, 2001, 91(2):953-962.
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  • 8Li L, Miano JM, Cserjesi P, Olson EN. SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic linea- ges during embryogenesis ~J]. Circ Res, 1996,78(2), 188-195.
  • 9Solway J, Forsythe SM, Halayko AJ, et al. Transcriptional regulation of smooth muscle contractile apparatus expression [J]. AmJ RespirCrit CareMed, 1998,158(5) :100-108.
  • 10Qiu P, Ritchie RP, Fu ZY, et al. Myocardin Enhances Smad3-Me- dinted Transforming Growth Factor 1 Signaling in a CArG Box Inde- pendent Manner [J]. Circ Res, 2005, 97(10) :983-991.

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国际呼吸杂志
2011年 第4期

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