N末端脑钠肽前体在维吾尔族心力衰竭中的诊断价值

Diagnostic value of plasma NT-proBNP in Uigur patients with chronic heart failure

目的探讨检测维吾尔族心力衰竭(CHF)患者血浆N末端脑钠肽前体(NT-proBNP)水平的临床意义。方法 78例维吾尔族心衰患者根据纽约心脏病协会(NYHA)分级标准分为心功能Ⅰ级(A组8例),Ⅱ级(B组19例),Ⅲ级(C组23例)及Ⅳ级(D组28例)4组,健康对照组51例。用电化学发光法检测NT-proBNP血浆浓度,心脏彩超检测其射血分数。结果心衰患者血浆NT-proBNP水平明显高于正常对照组[(6 329.7±4 697.4比77.9±53.8)pg/m l,P<0.001];不同NYHA心功能分级患者的血浆NT-proBNP浓度比较,可见两者随心功能级别增加而显著升高,且与汉族相同心功能分级无显著性差异。结论血浆中NT-proBNP水平可判断患者是否存在心衰可能;可作为维吾尔族患者心功能不全的检测指标,可判断心衰严重程度及指导临床治疗的指标。

Objective To explore the clinical significance of plasma N-terminal pro-brain natriuretic peptide（NT-proBNP） in patients of Uigur with chronic heart failure（CHF）.Methods Seventy-eight Uigur patients with CHF and 51 healthy subjects were investigated.Based on New York Heart Association（NYHA） grading criterion,the patients were divided into four groups： group A（8 cases）,group B（19 cases）,group C（23 cases） and group D（28 cases）.NT-proBNP was determined by electrochemiluminescence.Cardiac function was evaluated by ultrasonography.Results Plasma NT-proBNP level was significantly higher in patients with CHF than that in control group（6329.7±4697.4 vs 77.9±53.8 pg/ml,P0.001）.300 pg/ml of NT-proBNP could be used as the normal reference value to diagnose CHF with a sensitivity of 89.5%（70/78） and a specificity of 96.0%（49/51）.It was observed that plasma NT-proBNP concentrations were positively correlated with NYHA gradings,and did not show significant differences between Uigur and Han patients who had the same NYHA gradings.Conclusion Plasma NT-proBNP level may indicate the presence of CHF and the degree of cardiac dysfunction in Uigur patients,it can be used to help clinical treatment.