奥美拉唑联用莫沙必利治疗反流性食管炎疗效观察

Observation on therapeutic effect of omeprajole combined with mosapride curing reflux esophagitis

目的观察奥美拉唑联合莫沙必利治疗返流性食管炎的临床疗效。方法 120例反流性食管炎患者采用随机方法分成两组,每组60例,治疗组应用奥美拉唑和莫沙必利,对照组单用奥美拉唑,观察治疗前后患者的临床症状改善和内镜变化。结果治疗8周,治疗组症状改善明显优于对照组(P<0.05),内镜复查治疗组、对照组食管黏膜病损愈合总有效率分别为81.6%和51.7%,两组比较差异有统计学意义(P<0.05)。结论奥美拉唑和莫沙必利联用治疗反流性食管炎临床症状明显改善,联合用药临床疗效优于单用奥美拉唑。

Objective To observe the efficacy of omeprajole combined with mosapride in the treatment of reflux esophagitis（RE）.Methods 120 cases of RE was randomized to two groups,60 cases in each group.The treatment group were treated with omeprajole and mosapride.The control group were treated with omeprajole.The change in symptom and endoscope before and after treatment were observed.Results After treated for 8 weeks,the symptom had been improved obviously in treatment group（P0.05）.Esophageal mucosa erosion was coalesce,the percentage was 81.6% and 51.7%,there was significant difference with the two groups（P0.05）.Conclusion The efficacy of omeprazole combined with mosapride in the treatment of RE is better than that of omeprazole single,the clinical symptoms were markedly improved.