大鼠颈动脉内皮剥脱动物模型建立方法的研究

The study of establishing a rat carotid artery injury model

目的 探讨建立大鼠颈动脉内皮剥脱动物模型的方法 ,观察内皮剥脱后平滑肌细胞 (SMC)增殖反应。方法 采用自制 2FFogarty导管剥脱大鼠动脉内皮 ,观察SMC增殖。结果 内皮剥脱后即刻动脉、血管壁内皮细胞消失 ;内皮剥脱后 2天动脉、SCM轻度增生 ;内皮剥脱后 1周动脉SMC增生、管壁增厚 ;内皮剥脱后 2周动脉管腔内血栓形成伴机化 ,管腔闭塞 ,SMC增生 ;内皮剥脱后 4周动脉管腔内血栓机化 ,再通 ,部分管腔闭塞再通后管腔变窄 ,SMC增生。结论 大鼠颈动脉内皮剥脱后刺激血管SMC增生。

Objective To study the method of establishing a rat carotid artery model and observe SMC proliferation. Methods To observe SMC proliferation after balloon arterial injury in rat carotid artery. Results ① Endothelial cells couldn't be found in balloon injury artery , which meant that the method was reliable.② The artery was closed 2 weeks after balloon injury for the reason of SMC proliferation and migration. Conclusion SMC proliferation can be observed in the balloon injury. The model is well established.