荧光原位杂交检测早先受照者的染色体畸变

CHROMOSOMAL TRANSLOCATIONS IN ACCIDENTALLY IRRADIATED VICTIMES MEASURED BY FLUORESCENCE IN SITU HYBRIDIZATION

应用２号染色体特异性探针进行荧光原位杂交，研究６０Ｃｏγ射线照射诱发人外周血淋巴细胞染色体的易位畸变。结果表明，离体照射诱发的畸变率与剂量呈现良好的相关。６０Ｃｏ辐射事故受照者在照后第６、７年的易位畸变率保持相对稳定，约占照后立即检测双＋环畸变率的４０％～５０％，并且易位畸变率与最初照射剂量相关良好。

Translocation aberrations in human peripheral lymphocytes induced by 60 Co γ rays were measured using fluorescence in situ hybridization with chromosome 2 probe. A good dose effect relationship was observed for in vitro exposure. The translocation frequencies in the victims measured at the 6th and 7th year after exposure to 60 Co γ rays maintained a relative constancy,which amount to 40%～50% of dicentrics plus rings frequencies measured immediately after exposure,and the translocation frequencies were well correlated with the original dose. (