244例药品不良反应报告分析

Retrospective analysis on 244 cases of adverse drug reaction

目的了解我院药品不良反应(ADR)发生的特点及规律。方法收集我院2009年1月1日至2009年12月31日上报至全国药品不良反应监测网络的244例ADR报告,进行回顾性统计分析。结果 244例ADR中女性多于男性,61岁以上的老年人组发生率为最高,其次为21～30岁年龄组;最易引发ADR的给药途径是静脉滴注;引发ADR最多的药物种类为抗微生物类,占63.93%;主要累及器官或系统为皮肤及其附件。结论应加强ADR知识的培训,对抗微生物药和中药注射剂使用时应重点监测,合理应用抗菌药物,减少ADR的发生。

Objective To investigate the regularity and characteristic of adverse drug reaction（ADR） reported in our hospital.Methods A total of 244 ADR cases which were collected from our hospital from January,1,2009 to December,31,2009 had been reported to the national ADR monitoring network.Those cases were retrospectively analyzed.Results 244 cases of ADR in female was higher than in male,61 years old or older group had the highest rate,followed by 21 to 30 age group;Most likely caused by ADR route of administration was intravenous infusion,Most types of ADR caused by the anti-microbial drug class,accounting for 63.93%;Organ or system was mainly involved skin and its appendages.Conclusion Enhancing knowledge of ADR training,Antimicrobial drugs and Chinese medicine injections should be used with key monitoring,rational use of antimicrobial drugs,in order to reduce of ADR.