摘要
１８８Ｒｅ－硫化铼混悬液是由Ｎａ２Ｓ２Ｏ３和ＫＲｅＯ４以及Ｎａ１８８ＲｅＯ４在酸性溶液中反应制得１８８Ｒｅ－硫化铼沉淀，加入ＰＶＰ超声５ｍｉｎ后获得。其放化产率＞９６％，体外稳定性研究表明３ｄ内大于９９％的１８８Ｒｅ以硫化铼的形式存在，颗粒度主要为１～５μｍ。采取瘤内直接注射法将混悬液直接注入荷瘤鼠肿瘤（Ｓ－１８０肉瘤）内，放射性在瘤内３ｄ的保持率约为９０％。用生理盐水或非放硫化铼混悬液作对照组，结果表明１８８Ｒｅ－硫化铼对肿瘤抑制率达９６％。
Re rhenium sulfide suspension is formed by acid reduction of Na 2S 2O 3 in the
presence of KReO 4 including Na 188 ReO 4. The radiochemical yield is more than 96%.
The in vitro stability studies reveal that more than 99% of 188 Re remains in sulfide form
in 3 days. The major particle size is 1～5 μm. 188 Re rhenium sulfide suspension is
injected into tumors of mice and the tumor b ea ring mice are killed in certain interval. The
results of the biodistribution stu dy show that the mean retention percentages of 188 Re in
tumors are about 90% in 3 days. Compared with the control which is injected the inactive r
henium sulfide suspension or normal saline, the tumor inhibiting ratio by intra tumor injection
of 188 Re rhenium sulfide suspension is about 96% .
出处
《同位素》
CAS
1999年第2期74-78,共5页
Journal of Isotopes
关键词
混悬液
生物分布
肿瘤抑制率
镭-硫化铼
Re rhenium sulfide
suspension\ bio distribution\ tumor inhibiting ratio
