糖尿病患者血清唾液酸水平观察

Serum sialic acid level in diabetes mellitus

目的：观察糖尿病患者血清唾液酸（ｓＳＡ）水平。方法：应用快速比色法检测。结果：７８例糖尿病（ＤＭ）患者ｓＳＡ浓度（５７４．８７±１０２．３６）ｍｇ／Ｌ，明显高于４０名正常人（４７６．０５±７０．９６）ｍｇ／Ｌ（Ｐ＜０．０１）；ＤＭ组伴有并发症者ｓＳＡ浓度（６８１．２５±９６．４２）ｍｇ／Ｌ（ｎ＝２６）明显高于无并发症者（５２１．６８±５１．２０）ｍｇ／Ｌ（ｎ＝５２）（Ｐ＜０．０１）。结论：ＤＭ患者ｓＳＡ水平升高，且随ＤＭ的严重程度增加而升高。

Objective:To observe the level of serum sialic acid(sSA) in patients with diabetes mellitus(DM).Methods:The concentrations of sSA in 78 patients with DM and 40 normal individuals were determinated by spectrophotometry.Results:The levels of sSA in DM group (574.87±102.36)mg/L were obviously higher than those in normal individual group (467.05±70.96)mg/L .The difference between these two groups, t ′ test was significant( P <0.01).The levels of sSA in DM group with complication (681.25±96.42)mg/L, n =26 were obviously higher than those without complication (521.68±51.20)mg/L, n =52 ,their difference was also significant( P <0.01).Conclusions:The levels of sSA in patients with DM are elevated.