摘要
目的探讨解脲支原体(UU)感染与早产及胎膜早破的相关性。方法采用分离培养法,分别对46例胎膜早破和7例早产患者(试验组)以及32例正常妊娠(对照组)妇女的宫颈分泌物、胎膜和脐带进行UU检测;对部分试验组和对照组的胎盘组织进行电镜观察,并与阳性培养物负染电镜观察结果相比较。结果试验组宫颈分泌物、胎膜和脐带中UU检出率均为736%(39/53),对照组宫颈、胎膜和脐带中的UU检出率分别为406%(13/32)和156%(5/32),两组比较,差异有极显著性(P<0.01,P<0.001);UU阳性患者围产期死亡、死胎和低体重儿的发病率为341%(15/44),明显高于胎膜UU检出阴性的患者(73%,3/41,P<0.01)。电镜观察显示,从胎膜早破者胎盘组织的合体滋养层细胞的核膜周围及胶原纤维中见大量增殖的UU颗粒,并与负染电镜下所见的UU颗粒相一致。而在正常胎盘组织中未见到相同颗粒。结论UU感染是部分早产、低体重儿和胎膜早破的原因;滋养层细胞内UU的增殖,可诱发相应的细胞结构的改变,以致干扰胎儿的正常发育。
Objective To evaluate the relationships between ureaplasma urealyticum
(UU) infection and premature delivery or premature rupture of the membrane (PROM). Methods
The cervical swabs, fetal membrane and umbilical cord from 46 cases of PROM, 7 cases of
premature delivery (study group), and 32 normal pregnancies (control group) were cultutred for
UU. Some of these placenta tissues were examined under electron microscopy, and compared
with the purified UU. Results The detective rates of UU were both 73.6%(39/53) in the cervix
and fetal membrane of the study group, and to compare with the control group (40.6%, 13/32
and 15.6%, 5/32 respectivety), significant differences were shown (P<0.01, P<0.001). The
prevalence rate of perinatal mortality, stillbirth and low birth weight in UUpositive cases (34.1%,
15/44) was significantly higher than that in UUnegative cases (7.3%, 3/41, P<0.01). Electron
microscopy demonstrated that large amount of small multiplicated UU particles deposited
around the nuclear membrane of the cytotrophoblasts and in the collagen fibers from the
placenta of PROM, and its shape was in consistent with that of the purified UU. In contrast, no
UU particles was seen in the normal control group. Conclusion the results show that UU is
responsible for some cases of premature delivery, low birth weight and PROM. The
multiplication of UU within the trophoblasts may disrupt cell structure which could interfere the
normal fetal development.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1999年第5期287-289,共3页
Chinese Journal of Obstetrics and Gynecology
基金
浙江省教委科研基金
关键词
胎膜早破
早产
解脲支原体
Ureaplasma infectionsLabor, prematureFetal membranes,
premature ruptureMicroscopy, electron