THP定位诊断早期非肌层浸润性膀胱癌

Feasibility study of early localization diagnosis of THP(pirarubicin) on non-muscle invasive bladder cancer

目的:研究THP(吡柔比星)对非肌层浸润性膀胱癌早期的定位诊断效果。方法:选择35例已诊断膀胱癌或高度怀疑尿路上皮癌患者。病人术前及术后复查时,30mgTHP溶入50ml 5%葡萄糖液中,灌入已排空的膀胱中,保留15分钟,排出THP,彻底冲洗膀胱。普通膀胱镜检查,有THP吸收的非肿瘤区域取活检,无THP吸收的部位随机活检。结果:35例患者中存在非肌层浸润性膀胱癌早期的共6例。结论:THP对非肌层浸润性膀胱癌早期的定位诊断效果明确,安全性好。

Objective ： To study the feasibility of early localization diagnosis of THP （pirarubicin） on non - muscle invasive bladder cancer. Methods ： For 35 patients that had the diagnosis of bladder cancer or was highly suspected had carcinoma of urethra epidermis, before or after surgery, integrate 30mg THP into the 50ml 5% glucose,pour the glucose into empty bladder and keep it for 15 minutes,drain and rinse the bladder thoroughly. With normal eystoseo- py, the region with absorption of THP of non - tumor do biopsy and non - absorbed part of THP do random biopsy. Results：In 31 patients, there were 6 had early non -muscle invasive bladder cancer. Conclusion： For non -muscle invasive bladder cancer the early localization diagnosis of THP is clear and safe.