ROS介导的自噬及其在相关疾病中的作用

ROS-mediated autophagy and its role in the pathogenesis

传统观念认为,活性氧类（reactive oxygen species,ROS）只是一类损伤细胞的毒性物质,近年的研究发现ROS作为一种信号分子参与细胞的增殖、分化及凋亡等多个生理过程。自噬是一种溶酶体依赖性的细胞内大分子物质和细胞器的降解过程。

Reactive oxygen species（ROS） are generally small,short-lived and highly reactive molecules,and formed by incomplete one-electron reduction of oxygen.ROS act as signaling molecules involving in a variety of intracellular processes,such as proliferation,immunity and apoptosis.The intracellular excessive accumulation of ROS may cause oxidative stress,and eventually lead to cell death and to participate in the pathogenesis of many diseases.Autophagy,a process by which eukaryotic cells degrade and recycle macromolecules and organelles,plays an important role in the cellular response to oxidative stress.Here,we review the recent reports suggesting ROS of mitochondrial origin as signaling molecules in autophagy and its role in the pathogenesis.