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载脂蛋白M与动脉粥样硬化的研究进展 被引量：1

Recent advances in apolipoprotein M and atherosclerosis
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摘要 心、脑血管疾病的发生率及死亡率居各种疾病前列,动脉粥样硬化（atherosclerosis,AS）是其重要的病理基础,因此对动脉粥样硬化的研究具有极其重要的临床意义。动脉粥样硬化研究范围广泛,近年来,载脂蛋白与动脉粥样硬化关系的研究进展尤为迅速。 Atherosclerosis is a complex pathological process,which has a close relationship with inflammatory response and disorder of lipid metabolism.The cardioprotective role of high-density lipoprotein（HDL） is related to its characters of protecting the vascular endothelial cells and the properties of anti-inflammation and anti-oxidation.Low-density lipoprotein（LDL） and very-low-density lipoprotein（VLDL） are thought to have the adverse effects on human atherosclerosis.Apolipoprotein M（apoM,found in 1999） is an apolipoprotein mainly associated with HDLs.ApoM has a remarkable property of anti-atherosclerosis in animal experiment.However,recent studies have not yet been able to establish that apoM is a defining risk factor for human coronary heart disease,and the biological functions of apoM,including its potential role in human atherogenesis,need to be established.
作者 刘杨 张晓膺 罗光华
机构地区 苏州大学附属第三医院心胸外科 苏州大学附属第三医院综合实验室
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2011年第1期200-203,208,共5页 Chinese Journal of Pathophysiology
基金 国家自然科学基金资助项目(No.30972955)
关键词 载脂蛋白M 动脉粥样硬化 脂蛋白M HDL 脂质代谢 Apolipoprotein M Atherosclerosis Lipoproteins HDL Lipid metabolism
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献30

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二级参考文献16

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共引文献12

同被引文献6

  • 1Reaven GM. Insulin resistance : the link between obesity and cardio- vascular disease[J].Med Clin North Mn, 2011, 95 (5) : 875 - 892.
  • 2Hu YW, Zheng I,, Wang Q. Characteristics of apolipoprolein M and its relation to atherosclerosis and diabetes[ J ]. Biochim Biophys Ae- ta, 2010, 1801 (2): 100 -105.
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  • 6朱春华,王宗春,张晓膺,罗光华.载脂蛋白M的组织定位及其生物学意义的研究进展[J].国际检验医学杂志,2011,32(17):1967-1969. 被引量：1

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中国病理生理杂志
2011年 第1期

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