饮酒对全麻患者术后早期认知功能的影响

Influence of alcohol consumption on early postoperative cognitive function under general anesthesia in patients

目的研究饮酒对全麻患者术后早期认知功能的影响。方法采用神经心理学测试技术简易智力状态检查(MMSE)对40例长期大量饮酒者和40例匹配的正常对照者于术前1天及术后第3天评定认知功能,通过MMSE分值的变化来评价手术前后认知功能的改变及2组间的差异。结果饮酒组术后早期MMSE值低于对照组(P<0.05);饮酒组术后早期认知功能障碍(POCD)的发生率为37.5%,明显高于对照组的10.0%(P<0.05)。结论长期大量饮酒对全麻患者术后早期认知功能损害起促进作用。

Objective To explore the influence of alcohol consumption on early postoperative cognitive function under general anesthesia in patients.Methods Forty chronic alcoholics（alcohol drinking group） and 40 matched controls（control group） received neuropsychological test,the assessment of postoperative cognitive function referred to the scores that achieved in neuropsychological testing with mini mental state examination（MMSE） by special psychological person on the day before and the third day after surgery which was under general anesthesia.Finally,self-group difference and inter-group difference were compared.Results The score of MMSE was lower in exposure group than control group on the third day after surgery（P0.05）.The incidence of POCD on the third day after surgery was higher in alcohol drinking group than control group（37.5% vs.10.0 %）（P0.05）.Conclusion Drinking alcohol heavily and chronically may promote the incidence of damage on early postoperative cognitive function in the patients under general anesthesia.