直肠间质瘤16例临床分析

The clinical analysis of rectal gastrointestinal stromal tumor in 16 cases

目的探讨直肠间质瘤的诊断及治疗方法。方法回顾性分析16例直肠间质瘤的临床和病理资料。结果 16例均行手术治疗,其中12例行肿瘤完整切除术,2例行肿瘤不完整切除术,2例行探查术。其行肿瘤完整切除术者3年、5年生存率分别为66.7%、50.0%,中位生存时间为47个月。CD117,CD34表达率分别为87.5%、75.0%。结论 CD117和CD34是确诊直肠间质瘤最有价值的依据,肿瘤完整切除是直肠间质瘤的治疗原则。

Objective To investigate the methods of diagnosis and treatment of rectal gastrointestinal stromal tumor.Methods The clinical and pathological data of 16 cases with rectal gastrointestinal stromal tumor were retrospectively analyzed.Results All the cases underwent operation.In 12 cases,complete carcinectomy operation was done and 2 cases with incomplete carcinectomy operation.The 2 cases received exploratory operation.The 3～5 year survival rates of complete carcinectomy operation were 66.7% and 50.0%,respectively.The median survival time for 16 cases was 47 months.Immunohistochemical analysis displayed positive rates of expression for CD117 and CD34 were 87.5% and 75.0%,respectively.Conclusion For the rectal gastrointestinal stromal tumor,the most worthwhile diagnostic criterion was the presence of CD117 and CD34,and complete carcinectomy operation is the principal treatment.