血清免疫抑制酸性蛋白和免疫球蛋白亚类在白血病和骨髓瘤患者中改变

The serum levels of immunosupressive acidic protein and immunoglobulin subclasses in patients with malignant myeloma

目的：观察白血病和骨髓瘤患者血清免疫抑制酸性蛋白（ＩＡＰ），可溶性白介素２受体（ｓｌＬ２Ｒ）和免疫球蛋白亚类的变化。方法：应用单向免疫扩散法检测了患者血清免疫抑制酸性蛋白和ｌｇＡ亚类含量；双抗夹心酶联免疫吸附法检测了ｓｌＬ２Ｒ和ＩｇＧ亚类含量。结果：ＭＭ、ＡＬＬ、ＡＮＬＬ、ＣＬＬ和ＣＭＬ患者血清ＩＡＰ含量均明显高于正常对照组（Ｐ＜０００１）。ＭＭ、ＡＬＬ、ＡＮＬＬ和ＣＭＬ加速期患者血清ｓＩＬ２Ｒ含量明显高于正常；ＣＬＬ，ＣＭＬ慢性期未见异常。ＡＬＬ患者ＩｇＡ、ＩｇＡｌ、ＩｇＡ２、ＩｇＧ、和ＩｇＧ１含量均明显低于正常人；而ＡＮＬＬ、ＣＬＬ、ＣＭＬ未见明显异常。结论：ＩＡＰ和ｓＩＬ２Ｒ可作为恶性血液病诊断、疗效的监测指标，结合ＩｇＡ和ＩｇＧ及其亚类可作为综合评价免疫功能状态的指标。

Objective: To observe the changes of the serum levels of immunosupressive acidic protein(IAP), soluble interleukin2 receptor(sIL2R) and immunoglobulin (Ig) subclasses in patients with leukemia and mutiple myeloma(MM).ZMethods: The serum levels of IAP, sIL2R and Ig subclasses were measured in 65 cases of patients by using radioimmunodiffusion and enzymelinked immunoabsorbent assay(ELISA) Results: The serum levels of IAP and sIL2R in most patients with MM, acute lymphocytic leukemia(ALL), acute nonlymphocytic leukemia(ANLL), chronic lymphocytic leukemia(CLL),and chronic myelogenous leukemia (CML) were significantly higher than those of normal values.The serum levels of IgA and its subclasses,IgG and IgG1 in ALL patients were significantly lower than those of normal control(P< 005) Conclusion: The serum levels of IAP and sIL2R may be useful as clinical parameters for monitoring the disease stage, and response to treatment.With detecting to levels of IgA,IgG and their subclasses, the changes of IAP and sIL2R may be served as indicators to observe the condition of immune function of the patients.