丹皮总甙对小鼠化学性肝损伤的影响

Effects of total glucosides of mudan cortex on chemical liver injury in mice

目的观察丹皮总甙（ＴＧＭ）的抗肝炎作用。方法采用ＣＣｌ４和ＤＧａｌＮ诱导小鼠化学性肝损伤模型。结果ＴＧＭ可降低ＣＣｌ４和ＤＧａｌＮ所致血清ＡＬＴ、ＡＳＴ的升高，减轻ＣＣｌ４和ＤＧａｌＮ所致肝脏变性和坏死程度，预防给药效果优于治疗给药，其中以５０ｍｇ·ｋｇ－１剂量组给药７天效果最佳。结论ＴＧＭ对化学性肝损伤有一定程度的保护作用。

Objective To observe the effects of total glucosides of mudan cortex(TGM) on chemical liver injury. Methods Chemical liver injury model produced by CCl 4 and D Gal N in mice was applied. Results The elevation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum produced by CCl 4 and D Gal N were decreased by TGM, the degrees of degeneration and necrosis in liver produced by CCl 4 and D Gal N were diminished. The effect was more apparent in the preventive groups than in the therapeutic groups. The pretreatment group with a daily ig dose of TGM (50 mg·kg -1 ) for 7 days showed the most effective in all groups. Conclusion TGM shows some degree of protective effects on chemical liver injury. MeSH paeonia suffruticosa/pharmacol; glycosides/pharmacol; carbon tetrachloride; galactose; liver/pathol; liver diseases/chem induced; diseases models, animal; mice