视网膜下液载脂蛋白A-I的测定及临床意义

DetectionofapolipoproteinAIinthesubretinalfluidanditsclinicalsignificance

目的测定视网膜下液（ＳＲＦ）载脂蛋白ＡＩ（ａＰｏＡＩ）的含量，探讨其临床意义。方法采用单扩散法及酶法分别测定孔源性视网膜脱离（ＲＤ）病人视网膜下液及血液中ａＰｏＡＩ，ＣＨ，ＴＧ。结果ＳＲＦ中ａＰｏＡＩ含量与ＲＤ的范围密切相关，也与时间有关。ＳＲＦ中ａＰｏＡＩ、ＣＨ、ＴＧ与血液中ａＰｏＡＩ、ＣＨ、ＴＧ含量不相关。结论ａＰｏＡＩ与孔源性ＲＤ的发生、发展过程有关。

ObjectiveTodetectapoliproteinAI(aPoAI)inthesubretinalfluid(SRF)andtoinvestigateitsclinicalsignificance.MethodsaPoAI,cholesterol(CH)andtriglyceride(TG)weredetectedbyimmunodiffusionandenzymaticmethodrespectivelyintheSRFandbloodof32patientswithrhygmatogenousretinaldetachment(RD).ResultsTheleveloftheaPoAIintheSRFwaspositivelycorrelatedwiththetimeandrangeofRD(P<0.001).Whenthecourseofdiseaseexceededthreemonths,thelevelofaPoAIintheSRFwasnotincreased,butthelevelwashigherthanthatinonemonth.ConclusionTheresultssuggestthataPoAImaybeinvolvedinRD.