测定血清肌红蛋白水平对西宁地区脓毒症患者病情及预后判断的应用价值

The value of determination of serum myoglobin in estimation of degree of illness and prognosis of patients with sepsis in Xining area

目的 探讨血清肌红蛋白（MYO）对西宁地区脓毒症患者病情及预后判断的应用价值.方法 选择青海大学附属医院急诊重症监护病房（EICU）30例脓毒症患者,24 h内测定血清MYO水平并进行急性生理学与慢性健康状况评分系统Ⅱ（APACHEⅡ）评分.采用集束化治疗策略,判定28 d患者预后.比较存活组与死亡组血中MYO和APACHEⅡ评分,并对MYO和APACHEⅡ评分进行相关性分析;按MYO将患者分为＜500（10例）、500～1 000（14例）、＞1 000 μg/L（6例）3组,比较各组APACHEⅡ评分和死亡例数.结果 30例患者中存活16例,死亡14例.存活组血清MYO和APACHEⅡ评分明显低于死亡组[MYO（μg/L）：607.85±499.40比976.21±370.10;APACHEⅡ评分（分）：15.50±4.43比18.93±3.63,t1=2.28,t2=2.29,均P〈0.05].随着MYO升高,患者死亡例数明显增加（MYO＜500、500～1 000、＞1 000 μg/L组分别为2、7、5例,χ2=5.94,P〈0.05）,但APACHEⅡ评分差异无统计学意义.相关分析显示,血清MYO与APACHEⅡ评分呈明显正相关（r＝0.407,P〈0.05）.结论 测定MYO可反映西宁地区脓毒症患者的病情及预后.

Abstract：Objective To investigate the value of determination of serum myoglobin （MYO） in estimation of the degree of illness and prognosis of patients with sepsis in Xining area. Methods Serum MYO was measured and acute physiological and chronic health estimationⅡ （APACHEⅡ） score was evaluated in 30 cases with sepsis within 24 hours of admission to emergency intensive care unit （EICU）, and their correlation was analyzed. The patients were divided into two groups, survival group and death group according to the result within 28 days. The MYO and APACHEⅡ score were analyzed in both groups. All cases were divided into three groups： namely 〈500 （n=10）, 5001 000 （n=14）, 〉1 000 μg/L （n=6） groups, according to serum MYO value, and APACHEⅡ score and dead case were compared among three groups. Results Sixteen patients survived, and 14 patients died. The level of serum MYO and APACHEⅡ score were significantly lower in survival group than death group [MYO （μg/L）： 607.85±499.40 vs. 976.21±370.10, APACHEⅡ score： 15.50±4.43 vs. 18.93±3.63, t1=2.28, t2=2.29, both P〈0.05]. With the elevation of serum MYO, the dead case was increased in sepsis patients （the dead case in MYO〈500, 5001 000, 〉1 000 μg/L groups was 2, 7 , 5 cases, respectively, χ2=5.94, P〈0.05）, but there was no difference in APACHEⅡ score among three groups. There was significal positive correlation between serum MYO and APACHEⅡ score （r=0.407, P〈0.05）. Conclusion Determination of serum MYO can reflect degree of illness and prognosis of sepsis patients in Xining area.