益气通脉口服液对犬急性心肌缺血的影响

Effects of Yi Qi Tong Mai Oral Liquid on Acute Myocardial Ischemia in Dogs

为研究益气通脉口服液防治急性心肌缺血的作用，采用麻醉犬冠状动脉结扎建立心肌缺血模型，行心外膜电图标测和定量组织学（Ｎ－ＢＴ染色法）方法，研究消化道给药后对心肌缺血的影响。结果：实验组ＳＴ段升高总ｍＶ数（Σ－ＳＴ）在给药１５分钟至９０分钟期间较对照组明显降低（Ｐ＜０．０１）；ＳＴ段升高总点数（Σ－ＳＴ），实验组给药后３０分钟期间至１８０分钟较对照组明显减少（Ｐ＜０．０５）；Ｎ－ＢＴ染色见１０ｇ（生药）／ｋｇ剂量组梗塞区占全心及心室重量百分比较对照组明显降低（Ｐ＜０．０５）。结果提示该药能降低心肌梗塞程度和缩小梗塞范围，具有防治急性心肌缺血的作用。

The objective of this study was to assess the proplylactic and therapeutic effects of Yi Qi Tong Mai Oral Liquid (YQTMOL) on acute myocardial ischemia. The models of ischemia were made, in which the anterior coronary arteris of anesthetized dogs were ligated. Four groups of dogs were examined and compared. We determined the extent of their myocardial ischemia and infarction by means of epicardial mapping and NBT staining. The results showed that in the treatment groups, the increase of ST was inbibited 30180 minutes after the oral administration of YQTMOL(compared with control group, P<0.01), and the ST was decireased (P<0.05). Furthermore, in the group dosed with YQTMOL (10g/kg), the ratios of area of infarction/heart weight and area of infarction/ventricle weight both decreased (compared with control group, P<0.05). These findings in dicated that YQTMOL reduced the area of myocardial ischemia and the degree of myocardial infarction in dogs, so it could be effective for the prevention and treatment