青蒿琥酯与奎宁马斯静脉滴注治疗塞拉利昂儿童无并发症恶性疟疾的疗效比较

Control Study of Artesunate vs Quinimax Injection for the Treatment of Plasmodium Falciparum Malaria Without Complications in Children in Sierra Leone

【目的】比较青蒿琥酯针剂和奎宁马斯针剂治疗儿童恶性疟疾的疗效和副作用发生情况。【方法】对549例轻型恶性疟疾患儿随机分为两组，分别采用青蒿琥酯针剂（A组，n=293）和奎宁马斯针剂（B组，n=256）治疗，比较两组疗效和副作用发生情况。【结果】A组显效率高于B组（84．64％vs75．39％，P〈0．05）。而两组总有效率差异无统计学意义（97．95％vs95．70％，P〉0．05）；A组副反应发生率低于B组（3．75％vs10．54％，P〈0．05）。【结论】两种药物均适合用于恶性疟疾的治疗，但青蒿琥酯针剂起效更快，奎宁马斯要注意副作用的发生。

[Objective] To compare the therapeutic effect and side effects of artesunate vs quinimax injection for the treatment of plasmodium falciparum malaria in children. [Methods] Totally 549 children with mild plasmodium falciparum malaria were randomly divided into artesunate injection group（group A, n ： 293） arid quinimax injection group（group B, n ： 256）. The therapeutic effect and the incidence of side effects were com- pared between two groups. [Results] The excellence rate of group A was higher than that of group B（84. 64% vs 75.39（ P 〈0.05）, but there was no significant difference in the total effect rate between two groups（97. 95% vs 95.70, P 〉0.05）. The incidence of the side effects in group A was lower than that in group B（3.75% vs 10.54%, P 〈0.05）. [Conclusion] Both artesunate and quinimax injection are suitable for the treatment of plasmodium falciparum malaria,but the onset of the action of artesunate is faster than quinimax. The incidence of the side effects of quinimax should be noted.