地塞米松、爱氟龙及拂炎眼液对PRK术后眼压的影响

Effects of Dexmethason, Fluorometholone and Florex on Intraocular Pressure after Photorefractive Keratectomy

为探讨准分子激光屈光性角膜切削术（ＰＲＫ）术后分别使用０．１％地塞米松、爱氟龙及拂炎三种不同的皮质类固醇激素性眼液１～３个月对眼压的影响，作者总结和分析了共５４６只眼的随访资料。结果显示上述三种眼液引起眼压升高的比例不同，地塞米松组为３６％，爱氟龙组为１２．４％，拂炎组３１．９％。眼压升高最早可发生在用药后２周，但大多数在１月左右。有１１例双眼眼压升高的病例出现自觉症状，表现为视力下降、眼球胀痛、虹视等。其它病例没有任何自觉症状。在停用皮质类固醇激素和抗青光眼治疗３～７天后，眼压得到控制。作者认为，在ＰＲＫ术后使用皮质类固醇激素眼液２周以后就应进行眼科检查，以防治皮质类固醇激素性高眼压。

To evaluate the results of elevated intraocular pressure (IO) secondary to dropping of 0.1% Dexmethasone, Fluorometholone and Florex for 13 months after phatorefractive keratectomy, we summed up and analysed the 3month followup data on 546 eyes in three groups. The rates of IO elevated in Dexmethason, Fluorometholone and Florex were 36%,12.4% and 31.9% respectrively. After topical use of corticosteriod, some of the elevations of IO took place as early as two weeks, but most of them occurred around 1 month. Eleven patients with IO elevation of both eyes had visual acuity decreased associated with eyeache and halos and the other patients had no symptoms. After discontinuation of corticosteriod and institution of antiglaucoma therapy, the IO became normal in 37 daysAuthor . In practice, this means that patients receiving corticosteriod eyedrops for more than two weeks should be checked for the possibility of ocular hypertension to prevent the corticosteriod glaucoma.