let-7及其在肺癌中的作用

Let-7 and its function in lung cancer

肺癌中let-7表达普遍降低,而多种癌基因表达升高.导入let-7对肺癌细胞生长有明显的抑制作用.let-7有可能成为很好的靶点或者强有力的介入工具,将有望应用于肺癌的早期诊断、预后判断及治疗.

Let-7 is found to be downregulated in lung cancer while many kinds of oncogenes expression always increase, and restoration of the let-7 to normal expression level inhibits lung cancer growth evidently.Thus, let-7 might serves as good targets or effective interference tools in exploration of anticancer therapeutics,and has a good prospect in applying it in the early diagnosis, prognosis and therapy in lung cancer.