转录核因子-κB信号传导在消化道肿瘤中的研究进展

Advances in research of NF-κB signal transduction in gastrointestinal cancer

具有多向转录调节功能的转录核因子-κB（NF-κB）与胃、肠、肝等消化道组织细胞增殖和凋亡的失衡有关.其活化后产生的信号传导广泛参与了这些消化道肿瘤的癌前病变、肿瘤发生以及浸润、转移等过程.针对NF-κB活化途径的治疗,可以促进肿瘤细胞凋亡,削弱肿瘤对放化疗的抵抗能力并减轻肿瘤引起的恶病质.

NF-κB a factor possessing multiple transcription functions, has been demonstrated to have relation with the imbalance between cell proliferation and apoptosis in stomach, intestines, liver and other tissues of digestive tract. The active NF-κB signal transduction is extensively involved in the precancerous lesion,rumor development and invasion and metastasis. The therapies aimed at the activation of NF-κB can promote apoptosis of tumor cells, reduce the resistance against chemo-radiotherapy and relieve the cachexia caused by tumor.