危险饮酒不同酒龄对糖调节异常及动脉粥样硬化影响的研究

Research of the Relationship Between the Different Jeopardously Drinking Time and Impaired Glucose Regulation and Artheriosclerosis

目的探讨危险饮酒不同酒龄与糖调节异常（IGR）及动脉粥样硬化（AS）的关系。方法按相关标准确定危险饮酒研究对象528例（按不同酒龄分A1～A4组），非饮酒健康对照者96例（NC组），受试对象均为男性。检测受试对象收缩压（SBP）、舒张压（DBP），空腹血标本胰岛素（Fins）、血糖（FBG）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C），及进食75g葡萄糖后2h血标本血糖（2hBG）等指标，对检测结果及相关计算指标进行统计学分析。结果A1组与NC组间BMI、TG、TC、Fins、IR、ISE差异有统计学意义；A2组与NC组间仅IFG、HDL-C差异无统计学意义；A3、A4两组分别与NC组比较，各指标差异均有统计学意义。多元逐步直线回归分析证实危险饮酒时间与HDL-C呈负相关，与其他指标呈正相关。结论随着危险饮酒时间的增长，IGR（IFG、IGT）发生率显著增加，直至转化为T2DM；SBP、DBP显著增高，AS显著加重。控制饮酒量可以防止长期危险饮酒人群向T2DM和．AS转化。

Objective To explore the relationship between the duration of jeopardous drinking and impaired glucose regulation （IGR） and artheriosclerosis（AS）. Methods 528 cases with jeopardous drinking were selected according to related criteria,and di vided into 4 groups（A1 A4） according to the duration of jeopardous drinking. 96 cases without history of drinking were selected as healthy control （NC）. All subjects were adult male. SBP,DBP,and FIns,FBG,TG,TC, HDL-C,LDL-C of fasting blood sample,and 2 hBG of blood sample collected 2 h after intake of 75 g glucose were detected. Statistical analysis of the detection results and relat- ed calculated indicators were performed. Results There were statistical differences of BMI,TG, TC, Fins, IR, ISE and 2 hBG be- tween A1 and NC groups. Only differences of IFG and HDL-C between A2 and NC groups were statistically significant. There were no statistical differences of all indicators between A3, A4 and NC groups. Negative correlation of the duration of jeopardous drinking to HDL-C and positive correlations to the other indicators were confirmed by multiple stepwise linear regression analysis. Conclusion Along with the increase of duration of jeopardously drinking,IGR （IFG,IGT） is obviously aggravated or transformed to T2DM, SBP and DBP significantly higher and AS aggravated. Control of alcohol consumption can prevent the transformation of population with long-term jeopardous drinking to T2DM and AS.