血清降钙素原和C-反应蛋白联合检测在儿童肺炎支原体肺炎中的应用

Serum Procalcitonin and C-reactive Protein,Combined Detection of Mycoplasma pneumoniae Pneumonia in Children Withmycoplasma Pneumonia

目的探讨血清降钙素原（PCT）和C-反应蛋白（CRP）在儿童肺炎支原体肺炎（MPP）诊断、预后及疗效评价中的应用。方法选择MPP患儿54例，其中急性期32例，恢复期22例；健康体检儿童12例作为健康对照组。所有受试对象进行PCT、CRP检测，并对结果进行比较。结果急性期和恢复期患儿及健康对照组血清PCT值分别为0．27（0．17～0．35）、0．18（0．13～0．23）和0．14（0．13～0．16）μg／L，急性期组与恢复期组、急性期组与健康对照组差异有统计学意义（P〈0．05），恢复期组与健康组对照差异无统计学意义（P〉0．05）。急性期组和恢复期组血清CRP值分别为16．2（8．0～25．5）和8．0（8．0～8．0）mg／L，急性期组高于恢复期组（P〈0．05）。结论MPP患儿在急性期PCT、CRP仅轻度增高，恢复期降至正常范围。PQT测定有利于鉴别诊断细菌性肺炎和非细菌性肺炎。联合检测PCT及CRP在MPP的早期诊断及疗效判断方面有较高价值。

Objective Discussion of the Joint serum procalcitonin and C-reactive protein in children with mycoplasma pneumoni a. Methods The MPP diagnosed 54 eases of hospitalized children,including 32 cases of acute phase and recovery phase of 22 cases, 12 cases of normal medical examination of children as a control group. All children were admitted to hospital after taking blood to do blood PCT,CRP test,each group of PCT,CRP were compared. Results The acute phase and recovery phase serum PCT values were 0.27（0.17- 0. 35）μg/L,0.18（0.13--0. 23）μg/L,normal control group was 0.14（0.13--0.16）μg/L,acute observation peri od PCT Recovery period compared with the value of the difference was significant（P〈0.05）, and PCT normal recovery period there was no significant difference（P2〉0. 05）. Acute phase and recovery phase serum CRP values were 16.2（8.0--25.5）mg/L,8.0（8.0 --8.0）mg/L,higher than the acute phase of recovery（P〈0.01）. Conclusion Mycoplasma pneumonia in children with acute stage of PcT,CRP increased only slightly,the recovery fell within the normal range. PCT determination in favor of the differential diag- nosis of bacterial pneumonia and bacterial pneumonia. Combined PCT and CRP testing for the MPP in the early diagnosis and judge the efficacy has a higher value.