某地区医院洋葱伯克霍尔德感染的临床分布现状及耐药研究

Clinical Distribution and Resistant Investigation of Burkholderia cepacia in a Hospital of Ningbo City

目的了解本地区医院内洋葱伯克霍尔德菌(BC)临床分布状况及耐药特点,为合理选择抗菌剂提供依据。方法对本院各种标本中获得的319株BC进行鉴定和药敏试验。用WHONET5统计软件进行统计分析。结果药敏结果显示BC对复方新诺明3年平均耐药率为16.9%,对美罗培南耐药率为24.4%,对其他10种抗菌剂耐药率均大于50%。结论 BC所致院内感染不断增多,多药耐药菌株亦不断增加;复方新诺明和美罗培南是目前治疗多药耐药BC感染的最佳选择。合理应用抗菌剂,加强BC感染及耐药监测,是控制感染、防止暴发性流行、降低耐药率的重要措施。

Objective To investigate clinical distribution and resistame,and to provide reasonable antimicrobial agents to treat infection of Burkholderia cepacia. Methods Three hundred and nineteen strains of Burkholderia cepacia were collected from all sorts of clinical samples isolated in Ningbo NO. 1 Hospital, and were performed identification and antimicrobial susceptibility by VITEK-32. Then,the results were analyzed by WHONETS. Results Antimicrobial susceptibility showed that their resistant rates to trimethoprim-sulfamethoxazole, meropenem and cefoperazone/sulbactam were 14. 5 ~, 22.490~, and 49. 91%, respectively. And resistant rates to rest 9 kinds of antimicrobial agents were all higher than 50 ~. Conclusion Clinical infection of Burkholderia cepa- cia have increased in recently, and multi-drug resistant strains have mounted up obviously. And trimethoprim-sulfamethoxazole, meropenem were best antimicrobial agents to treat infection of multi drug resistant Burkholderia cepacia In addition,using antimicrobia agents reasonably, and strengthening surveillance of Burkholderia cepacia infection should be used to control infections, pre- vent from breaking out in a hospital,and decrease resistant rate.