hsCRP、UmAlb和HbA1c的相关性在2型糖尿病肾病早期实验诊断中的价值

The Early Diagnostic Value of hs-CRP,UmAlb and HbA1c in Diabetic Nephropathy Patients

目的探讨高敏C反应蛋白(hsCRP)、尿微量清蛋白(UmAlb)和糖化血红蛋白A1c(HbA1c)在2型糖尿病肾病早期诊断中的价值。方法 65例2型糖尿病(T2DM)患者按UmAlb排泄率分为早期糖尿病肾病组(EDN组)35例,无糖尿病肾病组(NDN组)30例;健康对照组(HC组)30例。测定并分析hsCRP、UmAlb、空腹血糖(FBG)、三酰甘油(TG)、总胆固醇(TC)、尿素氮(BUN)、肌酐(Cr)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和HbA1c。结果 EDN组hsCRP、UmAlb、HbA1c高于NDN、HC组,差异有统计学意义;在65例T2DM患者中,hsCRP、HbA1c与UmAlb呈正相关。结论 hsCRP、Um-Alb和HbA1c是2型糖尿病肾病早期诊断的重要指标,对糖尿病肾病的预防、诊断、治疗及预后有重要的监测意义。

Objective To discuss the value of hs-CRP,UmAlb and HbAlc in early diagnostics of diabetic nephropathy（DN） pa- tients. Methods 65 cases of type 2 diabetes mellitus（T2DM） patients were enrolled and divided into two groups according to the excretion rate of UmAlb, one group with early diabetic nephropathy （EDN, 35 cases）, the other without diabetic nephropathy （ NDN, 30 cases）. 30 healthy people were selected as health controls （HC）. hsCRP, UmAlb, fasting blood glucose（FBG）, triglyceride （TG）, total cholesterol （TC）, urea nitrogen （BUN）, creatinine （Cr）, l^igh density lipoprotein （ HDL-C）, low density lipoprotein （LDL-C） and HbAlc were detected and analyzed. Results hsCRP,UmAlb and HbAlc concentration of EDN group were signifi- cantly higher than NDN and HC group. In 65 cases of T2DM patients,there were positive correlation between hsCRP, HbAlc and UmAlb. Conclusion hsCRP,UmAlb and HbAlc are important indicators of early diagnosis of type 2 diabetic nephropathy patients and have important monitor significance for prevention,~reatment and prognosis of diabetic nephropathy patients.