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Th17细胞及其在神经免疫疾病中的作用 被引量：13

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摘要 研究者们在实验性自身免疫性脑脊髓炎（EAE）和胶原蛋白诱导性关节炎的鼠类模型中，发现了一种白介素（IL）-23相关的且能分泌IL17的新的Th细胞亚群-Th17细胞，为研究免疫调节、宿主防御、自身免疫性疾病和其他慢性炎症疾病的发病机理提供了全新途径。随着对Th17细胞的深入了解，研究者发现Th17细胞的免疫功能与神经免疫疾病密切相关，以下是详细介绍。
作者 陈怡丽 姜傥
机构地区 中山大学附属第一医院检验医学部
出处 《国际检验医学杂志》 CAS 2011年第2期242-244,共3页 International Journal of Laboratory Medicine
关键词 神经免疫调节 神经系统自身免疫性疾病 实验性 多发性硬化 自身免疫性脑脊髓炎 实验性 TH17细胞
分类号 R744 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献24

  • 1Acosta-Rodriguez EV,Napolitani G,Lanzavecchia A,et al.Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells[J].Nat Immunol,2007,8(9):942-949.
  • 2Afzali B,Lombardi G,Lechler RI,et al.The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease[J].Clin Exp Immunol,2007,148(1):32-46.
  • 3Bettelli E,Carrier YJ,Gao WD,et al.Reciprocal developmental pathways for the generation of pathogenic effector T(H)17 and regulatory T cells[J].Nature,2006,441(7090):235-238.
  • 4Veldhoen M,Hocking RJ,Atkins CJ,et al.TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells[J].Immunity,2006,24(2):179-189.
  • 5Spolski R,Leonard WJ.The Yin and Yang of interleukin-21 in allergy,autoimmunity and cancer[J].Curr Opin Immunol,2008,20(3):295-301.
  • 6Wilson NJ,Boniface K,Chan JR,et al.Development,cytokine profile and function of human interleukin 17-producing helper T cells[J].Nat Immunol,2007,8(9):950-957.
  • 7Harrington LE,Mangan PR,Weaver CT.Expanding the effector CD4 T-cell repertoire:the Th17 lineage[J].Curr Opin Immunol,2006,18(3):349-356.
  • 8Dong C.TH17 cells in development:an updated view of their molecular identity and genetic programming[J].Nat Rev Immunol,2008,8(5):337-348.
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二级参考文献15

  • 1Park H, Li Z, Yang XO, et al. A distinct lineage of CD4^+T cell regulate tissue Inflammation by producing interleuki 17[J]. Nat Zmmunnl,2005,6(11) : 1133- 1141.
  • 2Pene J, Chevalier S, Prcisscr L, et al. Chronically inflamed human tissues are infiltrated by high differentiated Th17 lymphocytes[J]. Immunol, 2008,18( 11 ) : 7423-7430.
  • 3Wang C, Kang SG,Lee J,et al. The role of CCR6 in migration of Th17 cells and regulation of effector T cell balance in the gut[J]. Nature,2009,10:173-183.
  • 4Nair RP. Ruether A, Stuart PE, et al. Polymorphisms of the IL- 12β and IL-23R genes are associated with psoriasis[J]. Invest Dermatol,2008,128(7) :1653-1661.
  • 5Xin L, Li Y, Soong L. Role of interleukin-1 in activating the CD11 thigh CD45 RB dendritic cell subset and priming Leishmania amazonensis specific CD4^+ T cell in vitro and in vivo[J]. Infect Immun,2007,75(10):5018-5026.
  • 6Bettelli E, Korn T, Oukka M, et al. Inductin and effector functions of Th17 cells[J]. Nature,2008,453(19) :1051-1057.
  • 7Korn T, Bettelli E, Gao W. et al. IL-21 initiates an alternative pathway to induce proinflammatory Th17 cells[J]. Nature, 2007, 448(26) :484-487.
  • 8Yang XO. Pappu BP, Nurieva R. et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma [J].Immunity, 2008, 28 (10) :29-39.
  • 9Hayashia K, Altman A. Protein kinase C theta(PKC-θ):a key player in T cell life and death[J]. Pharmacol Res, 2007,55(6): 537-544.
  • 10Elias KM, Laurence A, Davidson TS, et al. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Star-3/Star-5 independent signaling pathway[J]. Blood, 2008,111 (3): 1013-1020.

共引文献5

同被引文献172

引证文献13

二级引证文献59

国际检验医学杂志
2011年 第2期

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