接种不同剂量国产重组酵母乙肝疫苗效果分析

An Analysis of the Effect of Domestic Recombinant Yeast Heptatitis B Vaccine of Different Doses

目的了解不同剂量乙肝疫苗接种的效果,对乙肝疫苗合理接种提供依据。方法将近年有乙肝疫苗全程接种史但未产生抗-HBs的学生360人,以及近年无接种史且抗-HBs阴性者469人,将两类人群各分成3组,分别进行5μg、10μg、20μg国产重组酵母乙肝疫苗的接种,全程接种后1个月,观察各组学生抗-HBs阳转情况。结果无接种史者给予3种不同剂量乙肝疫苗的全程接种,抗-HBs阳转率达85.26%、87.82%、88.54%,差异无统计学意义(P>0.05)。有接种史未产生抗体组,接种5μg,10μg,20μg 3种疫苗剂量,抗体阳转率分别为34.17%、50.83%、61.67%,10μg组和20μg组均高于5μg组,差异有统计学意义(P<0.01),10μg组和20μg组间差异无统计学意义(P>0.05)。结论对于全程接种未产生抗-HBs者,随着剂量的增加抗-HBs的阳转率增高,建议给予10μg或20μg剂量疫苗全程再接种,一般人群给予5μg剂量疫苗即可。

Objective To understand the results of different doses of hepatitis B vaccine in order provide references for rational vaccination.Method We divided into 3 groups 360 students who had been vaccinated with hepatitis B vaccine without HBsAb and 469 students who weren＇t vaccinated with negative for HBsAb.They were vaccinated 5 μg,10 μg,20 μg respectively.They were under close inspection to observe the situation of turning positive for an HBsAb.Results The students not vaccinate before have been vaccinated 3 different doses,and positive rates of HBsAb were 85.26%,87.82%,88.54% respectively,which is of no statistical significance（P0.05）.The students vaccinated with hepatitis B vaccine without HBsAb have been vaccinated 3 different doses,and positive rates of HBsAb were 34.17%,50.83%,61.67% respectively,which is of statistical significance（P0.01）.Conclusion To the cases with immune tolerance,the positive rates of HBsAb rise with the increasing of the doses.So 10 μg is suggested for revaccination.And 5 μg is suitable for common cases.