芬太尼静脉麻醉下血浆cAMP、cGMP水平的变化

Changes of cAMP and cGMP in fentanyl anaesthesia

目的：测定芬太尼静脉麻醉对血浆ｃＡＭＰ、ｃＧＭＰ含量的影响。方法：应用微量输液泵对３３例行择期上腹部手术病人诱导后持续恒定静脉内输入芬太尼，３组剂量分别为：Ⅰ组２５（μｇ·ｋｇ－１·ｈ－１，ｎ＝１２）；Ⅱ组５（μｇ·ｋｇ－１·ｈ－１，ｎ＝１３）；Ⅲ组７５（μｇ·ｋｇ－１·ｈ－１，ｎ＝８），芬太尼静脉输入到手术缝皮后停止。分诱导前（Ｔ１）、气管插管后（Ｔ２）、手术７０ｍｎ时（Ｔ３）、术终（Ｔ４）４次采静脉血，用放射免疫法测定ｃＡＭＰ、ｃＧＭＰ含量。结果：插管后、手术７０ｍｉｎ时及术终与术前比较ｃＡＭＰ、ｃＧＭＰ的含量均无显著差异（Ｐ＞００５）；组间比较Ｔ４时段ｃＡＭＰ值Ⅲ组较Ⅰ组，ｃＧＭＰ值Ⅱ组、Ⅲ组较Ⅰ组有显著性降低（Ｐ＜００５）。结论：芬太尼可有效地抑制血浆ｃＡＭＰ、ｃＧＭＰ的含量升高。

AIM:To observe the effect of fentanyl anesthesia on cAMP and cGMP. METHODS:33 up-abdominal operation patients were continuously injected with fetanyl by constant-speed injection pump after induction, of which dosage of the three groups were: group Ⅰ 2 5(μg·kg -1 ·h -1 , n =12);group Ⅱ 5(μg·kg -1 ·h -1 , n =13); and group Ⅲ 7 5(μg·kg -1 ·h -1 , n =8). The injection stopped at saturing. Blood samples were gathered before induction, after tracheal intubation, 70 min after intubation and at the end of operation. Values of cAMP and cGMP were measured by radioimmunoassay. The data were processed by SPSS software bag. RESULTS:There were not much differences between values of cAMP and cGMP before and after operation, after intubation and at 70 min after intubation ( P >0 05). But at the end of operation, the cAMP of group Ⅲ decreased significantly comparing with groups Ⅰ and the cGMP of group Ⅱ and group Ⅲ also decreased significantly comparing with group Ⅰ. CONCLUSION:Fentanyl can inhibit the increases of cAMP and cGMP effectively.