透明质酸钠治疗膝骨关节炎长期疗效观察

Observation of the Effect of Long-term Sodium Hyaluronate Therapy on Degenerative Osteoarthritis of Knees

目的观察长期使用透明质酸钠治疗膝骨关节炎的疗效。方法于2002年1～5月,选择本科门诊患者68例,予以透明质酸钠关节内注射进行治疗,每周1次,连续5周1疗程,每6个月重复1疗程。参照Lequesne评估法制定观察表,分析比较治疗前、后效果。结果本组68例,其中有58例患者获得随访,平均治疗15个疗程,总有效率87.2%,治疗前后关节功能评分自身比较差异有显著性(P<0.01)。结论透明质酸钠适用于X线分级在IV级以下或Lequesne评分在14分以下的OA患者,长期关节内注射透明质酸钠可以获得安全、满意的疗效,而对于晚期关节结构改变严重的重度OA患者,长期疗效不满意。

Objective To observe the effect of long-term sodium hyaluronate therapy on degenerative osteoarthritis of knees. Methods From Jan 2002 to May 2002, 68 cases of degenerative osteoarthritis of knees were subjected to sodium hyaluronate intraarticular injection one time per week, for 5 weeks as a period of treatment, the period every 6 months was repeated. The conditions of the knees before and after the treatment were evaluated by score of Lequesne. Results 58 cases were followed up with an average of 15 periods. The total effectiveness rate was 87.2%. The score of Lequesne after the therapy was obviously higher than that before the therapy （P〈0.05）. Conclusion Long-term sodium hyaluronate intraarticular injection has a safe and satisfying effect on the patients with degenerative osteoarthritis of knees evaluated lower than IV by score of X-ray or lower than 14 by score of Lequesne. But it has a doubtful effect on the patients with severe degenerative osteoarthritis of knees, whose joint structure has totally got changed.