大肠癌并发贫血的相关因素探讨

Related Factors for Anemia in Large Bowel Cancer Patients

目的分析大肠癌患者的分期、血清白蛋白水平、化疗、性别、年龄等因素与贫血的相关性。方法用Access数据库界面录入2003年1月至2009年5月间收治的251例大肠癌患者病历资料,按UICC大肠癌TNM分期法(1997年)进行分期。运用SPSS12.0统计软件包分析大肠癌贫血的相关因素。结果总贫血发生率为29.88%,男性与女性贫血发生率差异无统计学意义(P>0.05);低蛋白血症和接受化疗的患者贫血发生率均明显高于血清蛋白正常与未化疗者(P<0.005);大肠癌患者不同病理分期其贫血发生率也不完全相同(P<0.05);最终进入Logistic回归模型的危险因素有3个,分别是血清白蛋白水平(X1)、化疗(X2)及分期(X3)。结论大肠癌患者贫血的发生与分期、化疗、血清白蛋白水平有一定关系。

Objective To analyze the correlation between anemia and the related factors,such as stage of the cancer,concentration of albumin,chemotherapy,gender,and age in patients with large bowel cancer.Methods The clinical data of 251 patients who had been treated in our hospital were collected using the access data base.TNM staging for large bowel cancer of UICC（1997） was adopted and the related factors for anemia of large bowelcancer were analyzed with statistical package SPSS 12.0.Results The incidence of anemia was 29.88% in all;the difference of anemia incidence between male and female was not significant（P0.05）;The incidence of anemia in patients with hypoproteinemia and those who had received chemotherapy was higher than that in patients with normoproteinemia and those who had not received chemotherapy（P0.005）;the incidence of anemia was different in patients with different stages of large bowelcancer（P0.05）.Three risk factors finally entered into the model of Logistic regression：level of serum albumin,chemotherapy and stage.Conclusion Stage,chemotherapy and concentration of album in are the related factors for anemia in patients with large bowelcancer.