家族性与散发性精神分裂症的临床特征对照研究

A controlled study of clinical features between familial and sporadic schizophrenia

目的探讨家族性与散发性精神分裂症临床特征的异同。方法对６４例家族性精神分裂症、１５３例散发性精神分裂症的临床资料进行对比分析。结果与散发性精神分裂症相比，家族性精神分裂症以阴性症状为主、疗效相对较差、易复发。结论家族性与散发性精神分裂症的临床特征存在明显差异。家族史的研究对分析精神分裂症的症状、采用治疗方法、判断预后及探讨精神分裂症新的分类方法具有重要价值。

Objective A controlled study of clinical features of familial and sporadic schizophrenia.Method 64 cases schizophrenic patients with positive family history were compared with 153 cases schizophrenic patients with negative family history.Result There significant differences on negative symptoms,prognosis,insignt and relapse rates between the patient and controlled groups.Conclusions There is closes association between family history and clinical features in schizophrenia.Family history might be a useful tool in the analysis of symptoms,prognosis,treatment,and classification of schizophrenia.