摘要
选用老年小鼠和A1C13溶液制备的拟痴呆大鼠动物模型(DMR),研究脑忆清胶囊(NYQ)对实验动物记忆功能的影响及其作用机理。结果表明,DMR大脑皮层组织(Cer)中胆碱酯酶(AchE)活性比正常大鼠提高(P<0.01),而老年小鼠Cer中M-受体Rt值比正常青年小鼠降低(P<0.01),NYQ可显著降低实验动物Cer中AchE活性(P<0.05~0.01),增加M-受体Rt值(P<0.05~0.01)。提示NYQ可通过降低实验动物Cer中AchE活性,增加M-受体Rt值而明显提高记忆能力,对老年痴呆有一定的治疗作用。
The effect and mechanism of Nao Yi QingZ Capsule( NYQ )on memory in aged mouse and dementia mimetic rat model which was set up with aluminum chloride solution were studied.The results showed that the M_cholinergic receptor was lowerd in the aged mice( PWT5BZ< 0.01 )and the activity of acetylcholinesterase(AchE)was increased in the cerebral cortex of dementia mimetic rats( P < 0.01 )as compared with the healthy young animals. NYQ could markedly reduce the AchE activity and elevate the M_cholinergic receptor( P < 0.050.01 )in the cerebral cortex,and improve their memory.These results suggest that NYQ is effective in preventing the retrogression of cerebral function and beneficial for the treatment of senile dementia.
出处
《中药新药与临床药理》
CAS
CSCD
1999年第3期153-155,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家医药管理局青年科研基金
关键词
脑忆清胶囊
药理学
记忆
早老性痴呆
Nao Yi Qing Capsule/pharmacology
Memory/drug effect
Cholinesterases/analysis
Receptors,Cholinergic/analysis
Dementia,Senile/TCM therapy