脑忆清胶囊对老年小鼠和拟痴呆大鼠记忆功能的影响

Effect of Nao Yi Qing Capsule on Memory in Aged Mice and Dementia Mimetic Rats

选用老年小鼠和Ａ１Ｃ１３溶液制备的拟痴呆大鼠动物模型（ＤＭＲ），研究脑忆清胶囊（ＮＹＱ）对实验动物记忆功能的影响及其作用机理。结果表明，ＤＭＲ大脑皮层组织（Ｃｅｒ）中胆碱酯酶（ＡｃｈＥ）活性比正常大鼠提高（Ｐ＜０．０１），而老年小鼠Ｃｅｒ中Ｍ－受体Ｒｔ值比正常青年小鼠降低（Ｐ＜０．０１），ＮＹＱ可显著降低实验动物Ｃｅｒ中ＡｃｈＥ活性（Ｐ＜０．０５～０．０１），增加Ｍ－受体Ｒｔ值（Ｐ＜０．０５～０．０１）。提示ＮＹＱ可通过降低实验动物Ｃｅｒ中ＡｃｈＥ活性，增加Ｍ－受体Ｒｔ值而明显提高记忆能力，对老年痴呆有一定的治疗作用。

The effect and mechanism of Nao Yi QingZ Capsule( NYQ )on memory in aged mouse and dementia mimetic rat model which was set up with aluminum chloride solution were studied.The results showed that the M_cholinergic receptor was lowerd in the aged mice( PWT5BZ< 0.01 )and the activity of acetylcholinesterase(AchE)was increased in the cerebral cortex of dementia mimetic rats( P < 0.01 )as compared with the healthy young animals. NYQ could markedly reduce the AchE activity and elevate the M_cholinergic receptor( P < 0.050.01 )in the cerebral cortex,and improve their memory.These results suggest that NYQ is effective in preventing the retrogression of cerebral function and beneficial for the treatment of senile dementia.