clusterin、bcl-2在非小细胞肺癌中的表达及其相关性

Clusterin and bcl-2 expressions and their correlations in non-small cell lung cancer

目的:研究clusterin、bcl-2在非小细胞肺癌(NSCLC)组织中的表达及其相关性,探讨其与非小细胞肺癌发生、发展的关系。方法:免疫组化pv9000通用型二步法检测53例NSCLC组织、20例癌旁组织中簇集蛋白(Clusterin)、bcl-2的阳性表达情况。结果:非小细胞肺癌组织clusterin、bcl-2阳性表达率高于癌旁组织(P<0.05);clusterin、bcl-2表达与肺癌TNM分期、分化程度及淋巴结转移均有关(P<0.05),但与组织学类型、性别、年龄无关(P>0.05);在非小细胞肺癌组织中,clusterin、bcl-2表达成正相关(r=0.396,P<0.05)。结论:clusterin和bcl-2的高表达可能与非小细胞肺癌的发生、发展和浸润有关,二者在肺癌的发生发展中可能存在协同作用。

Objective：To study the expressions of clusterin and bcl-2 and their correlations with non-small cell lung cancer（NSCLC）,and to discuss their significance in the occurrence and development of lung cancer.Methods：To examine the expressions of clusterin and bcl-2 in 55 samples of non-small cell lung cancer tissues and 20 samples of adjacent normal lung tissues by pv9000 immunohistochemistry.Results：The positive rates of clusterin and bcl-2 in NSCLC were significantly higher than those of adjacent normal lung tissue（P0.05）.The positive expression levels of clusterin and bcl-2 were associated with TNM stages,cell differentiation and lymph node metastases of NSCLC（P0.05）,but not associated with histological type,sex and ages（P0.05）;there was a positive correlation between clusterin and bcl-2 expression with NSCLC（r=0.396,P0.05）.Conclusion：The high expressions of clusterin and bcl-2 in NSCLC tissues may be related to the occurrence,development and invasion of tumor,clusterin and bcl-2 may have a synergistic effect on tumor progress.