三阴性乳腺癌120例术后免疫化疗的疗效观察

Efficacy observation of immune-chemotherapy in 120 triple negative breast cancers after operation

目的:观察高聚生配合使用多西他赛为主的化疗方案在三阴性乳腺癌术后治疗中的疗效及不良反应。方法:选择120例三阴性乳腺癌患者,随机分为两组,比较分析4～6周期TE方案化疗及TE方案同时配合使用高聚生化疗后的近、远期疗效和不良反应。结果:治疗组骨髓抑制和胃肠道反应低于对照组(P<0.05),1、3、5年的无病生存率对照组与治疗组相比明显降低,差异有统计学意义(P<0.05)。结论:TE方案治疗受体三阴性乳腺癌疗效显著,配合使用高聚生可以提高缓解率,增强机体免疫功能,降低不良反应的发生率,近远期疗效显著。

Objective：To observe the efferts and toxicity of the chemotherapy of the docetaxel combined with HAS on the triple negative breast cancer.Methods：120 patients with triple negative breast cancer were chosen and diveded into 2 groups,one group was treated with chemotherapy by program TE combine with HAS far 4～6 cycles and another group was treated with chemotherapy by program TE.The short-term and long-term effieacy and toxicity of the treatment were evaluated after chemotherapy.Results：Compared with the control group,the bone marrow depression and gastrointestinal reaction in the cherapeutical group were siginificantly decreased.The disease free survival rate in 1、3、5 years in the control group was obviously lower than that in the therapeutic group with statistical difference（P0.05）.Conclusion：Chemotherapy regimen TE is obviously effective to treat triple negative breast cancer.HAS combined with rigimen TE not only improves the remission rate and immune function but also decreases the adverse reaction incidence.