胎盘生长因子与细胞缺氧关系研究进展

Research progress on relationship between placental growth factor and cell hypoxia

胎盘生长因子(PLGF)属于血管内皮生长因子(VEGF)家族成员,丰富表达于正常胎盘,主要由滋养叶细胞分泌,具有促进滋养细胞增殖和介导血管生成等作用。近年,对该因子在低氧条件下促进血管生成、调节滋养细胞功能、加快缺血性疾病进程及促进肿瘤等方面的作用有了新的认识。

Placental growth factor,a member of vascular endothelial growth factor family,is mainly expressed in normal placenta and secreted prominently in trophoblasts with the effects stimulating proliferation of trophocytes and mediating angiogenesis.In recent years,there have been some new understandings about its roles under hypoxia,such as stimulating angiogenesis,adjusting trophocytes function,accelerating ischemic diseases,promoting tumor and so on.