邻氯苯乙酸的合成研究

Study on synthesis of o-clorophenylacetic acid

本文研究了八羰基二钴催化合成邻氯苯乙酸,考察了不同反应条件对产率的影响,优化出最佳反应条件。实验表明:在常压下,醇水体积比为2∶1,碱质量分数为30%,催化剂与邻氯氯苄物质的量比为1∶40,反应温度为50℃,产率可达74.5%。

O-Clorophenylacetic acid was synthesed by catalyst of dicobalt octacarbonyl.The influential factors on the reaction were investigated.The optimum condition was obtained.The experimental results indicated the optimum conditions were： at atmospheric pressure,the volume ratio of methanol and water was 2∶1,alkaline concentration was 30%,the molar ratio of catalyst and o-chlorobenzyl chloride was 1∶40,the temperature of reaction was 50 ℃.The yield could reach 74.5%.