赤芍、白芍对环磷酰胺所致的血虚证小鼠补血作用比较研究

The Comparative Study of Blood Enrichment Effects on Blood Deficiency Mice Caused by Cyclophosphamide through Radix Paeoniae Rubra and Radix Paeoniae Alba

目的:研究赤芍、白芍在补血作用上的异同。方法:采用腹腔注射环磷酰胺100mg.kg-1、每日1次、连续3d的造模方法,灌胃给药,定期采血检测血常规。结果:造模12d,给药组的RBC、HGB、HCT值明显回升,且白芍的药效优于赤芍。结论:对于环磷酰胺所致的血虚证小鼠模型,白芍升高红细胞数、血红蛋白含量、红细胞压积的作用与模型组相比具统计学意义,而赤芍作用相对较弱。

Objective：Radix Paeoniae Rubra and Radix Paeoniae Alba, as traditional Chinese medicine, were used in clinics for so many years. Comparing their different effects on blood deficiency by Pharmacological ex- periments to provide the scientific basis of clinical medicine is the main purpose of this experiment. Methods： The model was replicated by intraperitoneal injection of 100rag-kg-i per day for three days. And the blank control group was given intraperitoneal injection the same Volume^s Physiological Saline. Results： At the 12th day, the Routine blood test showed that the RBC, HGB, treatment group had better recovery than model group, and was better than the extracts of Radix Paeoniae Rubra. HCT of model group significantly decreased. The the effect of the extracts of Radix Paeoniae Alba