HBV感染不同免疫状态患者血清中可溶性细胞间粘附分子-1水平的变化

Relationship between the different immune status of HBV infection and the expression of sICAM-1

目的:探讨可溶性细胞间粘附分子-1(sICAM-1)在乙型肝炎病毒(HBV)感染不同免疫状态及HBV感染相关原发性肝癌(PHC)患者血清中的变化及其意义。方法:将HBV感染者及HBV感染相关PHC患者分为5组:HBV感染免疫耐受组80例、免疫清除组80例、免疫不全组80例(其中分免疫不全A组40例、B组40例)和PHC组80例;另选40名非HBV感染健康体检者作为正常对照组,利用ELISA法对5组者及对照组血清sICAM-1水平进行测定。结果:HBV感染不同免疫状态者中免疫清除、免疫不全B及HBV感染相关PHC患者较正常对照组有不同程度的升高,差别有统计学意义(P<0.05);免疫耐受、免疫不全A组与正常对照组相比差别无统计学意义(P>0.05)。结论:血清sICAM-1变化对于判断HBV感染不同免疫状态病情变化,有一定的临床价值。

Objective：To study the expression and significance of the serum levels of soluble intercellular adhesion molecule-1（sICAM-1） in patients with different immune status of hepatitis B virus（HBV） infection and Primary Hepatocellular Carcinoma（PHC）.Methods：The patients of HBV infection were grouped into five teams,80 cases of immune tolerance to HBV,80 cases of immune clearance,immunodeficiency（A） and immunodeficiency（B） with 40 patients in either groups,and 80 patients diagnosed as PHC clinically.Serum samples were collected from these patients,and from 40 healthy volunteers as control for the study.Serum levels of sICAM-1 were measured by enzyme-linked immunosorbent assay（ELISA）.Results：Serum levels of sICAM-1 in patients with immune clearance,immunodeficiency（B） and PHC were significantly increased,comparing with that of normal control（P〈0.05）.Serum levels of sICAM-1 in patients with immune tolerance,immunodeficiency（A） were not significantly different compared with that of normal control（P〉0.05）.Conclusion：Serum levels of sICAM-1 may reflect the disease progressed in patients with different immune status of HBV and have certainly valuable for clinical significance.