摘要
目的:探讨CD58/CD2在宫颈癌患者的表达水平及临床意义。方法:分别应用免疫组织化学技术及流式细胞术检测40例宫颈癌患者及30例C IN患者组织CD58水平和外周血CD2+细胞百分率,以30例子宫肌瘤患者作为正常对照。结果:宫颈癌患者外周血CD2+细胞百分率及癌组织CD58表达水平均明显低于C IN组及正常对照组,差异均具有统计学意义(P<0.05)。结论:CD58/CD2的表达与宫颈癌的发生、发展有关,二者可作为治疗及评价预后的参考指标。
Objective： To explore the expression level of CD58/CD2 and its clinical significance in patients with uterine cervix cancer. Methods： Immunohistochemistry method was used to detect the expression of CD58 and flow eytometry was used to detect the CD2 expression in 40 patients with uterine cervix cancer arid 30 CIN patients, 30 cases of hysteromyoma were collected as normal controls. Results： The expression of CD2 and CD58 in patients with uterine cervix cancer were significantly lower than those in CIN patients and normal controls respectively （P 〈 0. 05 ） . Conclusion： The expression of CD58/CD2 are correlated with the development of uterine cervix cancer, they can be seen as the index for evaluation of treatment and prognosis.
出处
《中国妇幼保健》
CAS
北大核心
2011年第2期268-269,共2页
Maternal and Child Health Care of China
基金
无锡市科技局科研项目〔CSE00949〕
南京医科大学科技发展基金面上项目〔08NMUM080〕
