吡格列酮对初诊2型糖尿病患者血脂水平的影响及临床意义

Significance of Pioglitazone on Blood Lipids Spectrum of Type 2 Diabetes

目的:观察吡格列酮对初诊2型糖尿病(T2DM)患者血脂水平的影响。方法:98例初诊T2DM患者随机分为两组:治疗组,用吡格列酮加二甲双胍治疗;对照组,用安慰剂加二甲双胍治疗,均治疗12周,观察治疗前后两组血糖指标空腹血糖(FBG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)及血脂指标甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的变化。结果:治疗后,两组FBG、2hPG、HbA1c均明显下降(P<0.05)。治疗组患者TG、TC、LDL-C水平明显下降(P<0.05),HDL-C明显升高(P<0.05);对照组TG和LDL-C无明显改变,TC明显下降,HDL-C明显升高,但是幅度均低于治疗组(P<0.05)。结论:吡格列酮可提高对初诊T2DM患者血脂代谢紊乱的改善作用,吡格列酮和二甲双胍合用的降血糖效果优于单用二甲双胍。

Objective:To observe the effect of pioglitazone on blood lipids in preliminary diagnosis type 2 diabetes mellitus(T2DM). Method:98 preliminary diagnosis T2DM patients were divided into two groups randomly,and therapy group was treatment with pioglitazone and metformin,and control group was with placebo and metformin for 12 weeks,so that the level of blood glucose and blood lipids were detected before and after therapy.Results:Level of FBG,2hPG and HbA1c were lower in two groups after therapy(P<0.05),and therapy group was more obviously(P<0.05). The level of TG,TC,LDL-C was lower obviously,and HDL-C was higher significantly in therapy group (P<0.05),however,in control group,the change of TG and LDL-C was insignificant,and HDL-C was obviously improving(P<0.05),which was less effective than therapy group (P<0.05). Conclusion:Pioglitazone can ameliorate lipid disorders in preliminary diagnosis T2DM,and unite of pioglitazone and metformin had an advantage than single metformin in reducing blood glucose.