C反应蛋白在COPD急性加重期的临床价值

Clinical value of CRP in acute aggressive period patients with COPD

验证慢性阻塞性肺疾病（ＣＯＰＤ）急性加重期，Ｃ反应蛋白（ＣＲＰ）作为观察指标的价值一方法ＣＯＰＤ急性加重期患者４Ｄ例，均为抗生素治疗有效且中途未换用其它抗生素。人院后ｄ１。３、５、７、１４分别检测ＣＲＰ、ＷＢＣ、ＥＳＲ，人院时及人院后ｄ７、１４摄Ｘ线胸片，同时观察日最高体温和咳嗽频率、难度、痰粘度及肺部体征。结果人院时ＣＲＰ均＞８．０ｍｇ／Ｌ，阳性率为１００％，与ＷＢＣ、ＥＳＲ．Ｔ的阳性率相比差异有显著性（Ｐ＜０．０１或Ｐ＜０．０５），ＣＲＰ在ｄ１、３、５、７、１４天时分别为６３．８±２０．２、４２．０±１４．０、２３６±７．１、１０．７±３．５、３．１±０．７ｍｇ／Ｌ，峰值在第１天，随炎症好转ＣＲＰ逐渐下降，ＣＲＰ的变化与日最高体温的变化有良好相关性（ｒ＝０．７１Ｐ＜０．０５），与其它观察指标无相关性（Ｐ＞０．０５）。结论ＣＲＩ，在ＣＯＰＤ急性加重期是一个良好的观察指标，可反映抗生素的即时疗效，比ＷＢＣ、ＥＳＲ更迅速且敏感，与日最高体温变化有较好的相关性。

Objective To explore clinical value of C - reative protein(CRP) in acute aggressive pened ofchronic obetruchve pdrinaly disease(COPD). Methods 40 Patients in acute aggressive penal with COPD wereselected, who were all effective to antibiotic and not changed in griddle of the test. CRP.WBC.are were detected atday 1 .3 .5 .7. 14, elfest x - ray were taken, Oborved the highest day temperature, the frequency .degree .cifficulty ofcough and chest sign at day 1 .7. 14. Results The level of CRP all> 8.0mg/L at day l, the positive rate was100%, there were significantly difference compared with WBC.ESR. The CRP level was 63.8 ± 20.2.42.0 ± 14.0.23.6 ± 7. 1 .10.7 ± 3.5.3. 1 ± 0.7mg/L at day I .3.5.7.14 respechxrely. The highest leVel occur at day 1, hutgradually decreed. There were good correlative between CRP and the highest day temperatUre, and cd corrlativewith other markers. Conclusion CRP is a good marker in acute aggressive pened with COPD, it can expare immediate effectiveness of antibiohc selected, and is mere sensitive and rapid compared with WBC.ESR, it is rela-tive with the highest day temperature.