摘要
目的：探讨乙型、丙型、丁型和戊型肝炎病毒（ＨＢＶ、ＨＣＶ、ＨＤＶ和ＨＥＶ）感染对肝细胞癌（肝癌）发生的意义。方法：采用放射免疫法、酶联免疫法和聚合酶链反应法对７１例宁波地区肝癌患者ＨＢＶ、ＨＣＶ、ＨＤＶ和ＨＥＶ血清标志及血浆ＨＢＶ、ＤＮＡ和ＨＣＶ、ＲＮＡ进行检测。结果：ＨＢｓＡｇ和／或ＨＢＶ、ＤＮＡ总阳性率为９１．５４％，ＨＤＶ阳性率为１２．６８％，ＨＥＶ阳性率为２．８２％，而抗—ＨＣＶ和／或ＨＣＶ、ＲＮＡ阳性率却为零。结论：宁波地区肝癌发生，以ＨＢＶ感染占绝对优势，ＨＢＶ和ＨＤＶ重叠感染可能促进肝癌发生，ＨＥＶ在肝癌病因中作用可引起注意，而ＨＣＶ感染在宁波地区似与肝癌发生无明显相关性。
Objective: ST5,5BZTostudytherelationshipbetweenserologicmarkersofHBVHVCHDVandHEV, Methods: HBVDNAHCVRNAandpresenceofcarcinomain71hepatocellularcarcinoma(HCC)casesfromNingbo. ELISARIAandPCRtechniqueswereused. Results: ItwasfoundthatthepositiverateofHBsAgand/orHBVDNAwere91.54%.ThepositiverateofHDVwas12.68%andHEVwas2.82%.ButantiHCVand/orHCVRNAwereallnegative. Conclusion: ItissuggestedthatHBVwassignificanthighlywithHCVinNingbo.SuperinfectionofHBVbyHDVwouldincreasetheriskinthedevelopmentprocessofHCV.WhetherornotHEVwouldbesignificantwithHCVremainstobeinvestigated.
出处
《河北医学》
CAS
1999年第8期20-22,共3页
Hebei Medicine
关键词
肝炎病毒
肿瘤发生
肝细胞癌
HepatitisBvirus
HepatitisCvirus
HepatitisDvirus
HepatitisEvirus
Hepatocellularcarcinoma
