摘要
2-(2-氨基乙氧基)乙醇溶于乙醇,用叔丁氧羰基酸酐(Boc2O)进行氨基保护得N-叔丁氧羰基-2-(2-氨基乙氧基)乙醇,与1-氯-6-溴己烷在正己烷及50%NaOH和四丁基溴化铵作用下缩合,得N-叔丁氧羰基-2-(2-(6-氯己氧基)乙氧基)乙氨,最后在二氯甲烷及三氟乙酸混合液中脱保护,得标题化合物,总收率11.4%。
Firstly,2-(2-aminoethoxy)ethanol reacted with di-tert-butyl dicarbonate(Boc2O) in ethanol solution for protecting the amino group.Then the condensation of the thereby obtained tert-butyl-(2-(2-hydroxy) ethyl) carbamate with 1-bromo-6-chlorohexane was carried out in the presence of NaOH(50%) and tetrabutylammonium bromide to form tert-butyl(2-(2-(6-chlorohexy)oxy)ethyl)carbamate.Finally,tert-butyl(2-(2-(6-chlorohexy)oxy)ethyl)carbamate was subjected to de-protection in a mixture of dichloromethane and trifluoroacetic acid to yield(2-(2-(6-chlorohexy)oxy)ethyl)carbamate,with an overall yield reaching 11.4%.
出处
《化学试剂》
CAS
CSCD
北大核心
2011年第2期161-163,共3页
Chemical Reagents
基金
国家自然科学基金资助项目(30701042)