2-(2-(6-氯己氧基)乙氧基)乙氨的合成

Preparation of 2-(2-((6-chlorohexyl)oxy)ethoxy) ethanamine

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摘要 2-(2-氨基乙氧基)乙醇溶于乙醇,用叔丁氧羰基酸酐(Boc2O)进行氨基保护得N-叔丁氧羰基-2-(2-氨基乙氧基)乙醇,与1-氯-6-溴己烷在正己烷及50%NaOH和四丁基溴化铵作用下缩合,得N-叔丁氧羰基-2-(2-(6-氯己氧基)乙氧基)乙氨,最后在二氯甲烷及三氟乙酸混合液中脱保护,得标题化合物,总收率11.4%。 Firstly,2-(2-aminoethoxy)ethanol reacted with di-tert-butyl dicarbonate(Boc2O) in ethanol solution for protecting the amino group.Then the condensation of the thereby obtained tert-butyl-(2-(2-hydroxy) ethyl) carbamate with 1-bromo-6-chlorohexane was carried out in the presence of NaOH(50%) and tetrabutylammonium bromide to form tert-butyl(2-(2-(6-chlorohexy)oxy)ethyl)carbamate.Finally,tert-butyl(2-(2-(6-chlorohexy)oxy)ethyl)carbamate was subjected to de-protection in a mixture of dichloromethane and trifluoroacetic acid to yield(2-(2-(6-chlorohexy)oxy)ethyl)carbamate,with an overall yield reaching 11.4%.

作者林润锋张珩钟武

机构地区军事医学科学院毒物药物研究所武汉工程大学绿色化工过程省部共建教育部重点实验室

出处《化学试剂》 CAS CSCD 北大核心 2011年第2期161-163,共3页 Chemical Reagents

基金国家自然科学基金资助项目(30701042)

关键词 HALO Tag蛋白标记 2-(2-(6-氯己氧基)乙氧基)乙氨 WILLIAMSON 反应 Halo Tag protein labeling 2-(2-((6-chlorohexyl)oxy)ethoxy)ethanamine Williamson reaction

分类号 O622.6 [理学—有机化学]

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化学试剂

2011年第2期

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2-(2-(6-氯己氧基)乙氧基)乙氨的合成

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