重症监护病房鲍氏不动杆菌的耐药性调查

Antimicrobial resistance of acinetobacter baumanii in intensive care unit

目的探讨重症监护病房(ICU)医院感染鲍氏不动杆菌(ABA)的耐药现状,为临床医师诊断和治疗疾病提供科学依据。方法 237株ABA分离鉴定严格按《全国临床检验操作规程》进行;药敏试验采用K-B法,依据CLSI 2008-2009年折点判读结果。结果 ICU医院感染的ABA在呼吸道标本中检出率最高,69.2%;ABA对常用的14种抗菌药物均产生了不同程度的耐药性,对亚胺培南和美罗培南耐药率均达到27.8%,且ICU ABA泛耐药菌株检出率为13.9%。结论应加强对多药耐药ABA的监测,预防与控制ABA医院感染暴发流行。

OBJECTIVE TO investigate the antimicrobial resistance in nosocomial infection with Acinetobacter bau- manii （ABA） in intensive care unit （ICU） to provide the scientific evidence for clinical diagnosis and treatment. METHODS Referring to National Guide to Clinical Laboratory Operation Procedures, 237 ABA strains were isolated and identified. The susceptibility test was performed by K-B methods. The testing results were read according to CLSI 2008--2009. RESULTS Specimen of respiratory tract got the highest detection rate of 69.2%. The susceptibility results showed ABA isolates were resistant to 14 commonly used antibiotics in different degrees. The resistant rates of ABA to imipenem and meropenem arrived at 27. 8%. The isolating rate of pan- resistant strains was 13. 9%. CONCLUSION Hospitals should strengthen the monitoring of multi-drug resistant ABA to prevent and control the outbreak and prevalence of nosocomial infections.