广西壮族地区妇女生殖道支原体属耐药趋势研究

Drug resistant trend of mycoplasma in reproductive tract of women in Guangxi Zhuang Autonomous Region

目的探讨2005-2009年广西壮族地区妇女生殖道支原体属对抗菌药物耐药趋势,为临床合理用药提供依据。方法采用微量肉汤稀释法对支原体属进行耐药性监测。结果 2005-2009年支原体属对喹诺酮类抗菌药物耐药率呈逐年上升趋势;解脲脲支原体对大环内酯类抗菌药物2005-2007年耐药率逐年上升,2007年后呈逐年下降趋势,罗红霉素在2005-2009年耐药率分别为32.65%、40.12%、44.66%、33.28%和29.35%;2007年起解脲脲支原体+人支原体共发现7株对多种抗菌药物全部耐药菌株。结论加强支原体属耐药监测,根据药敏结果使用抗菌药物,可防止对多种抗菌药物全部耐药菌株产生。

OBJECTIVE To explore the drug resistance trends of mycoplasma in women＇s reproductive tract in Guangxi Zhuang autonomous region during 2005--2009 and provide a scientific basis for clinical rational use of drugs. METHODS Micro-broth dilution method was used for monitoring the drug-resistant mycoplasma. RESULTS Antibiotic resistant rate of mycoplasma to quinolones showed a rising trend year by year during 2005-- 2009 ;antibiotic resistance rate of Uu to macrolides increased year by year during 2005--2007, while it reached the peak in 2007 and then showed a declining trend. The drug resistant rates to roxithromycin during 2005- 2009 were 32.65% ,40.12% ,44.66% ,33.28% and 29.35%, respectively. Since 2007, 7 UU ＋ MH resistant strains were found. CONCLUSION Strengthening the surveillance to drug resistance of mycoplasma and rational application of antibiotics in accordance with drug sensitive test can prevent the occurrence of multi-drug resistant strains.