疏肝法治疗经前期综合征的系统评价

A Systematic Review of Smoothing Liver Therapy in Treating Premenstrual Syndrome

目的:系统评价疏肝法中药复方治疗经前期综合征(PMS)的临床疗效和安全性。方法:检索从数据库建库至2008年12月疏肝法中药复方治疗PMS的中、英文随机对照临床研究文献,对纳入研究的方法学质量进行评价。采用Revman5.0软件进行统计分析。结果:共获得临床试验研究论文16篇,其中随机对照试验研究论文5篇,纳入系统评价共1171例患者。由于纳入的各项研究采用不同的中药处方或对照,存在临床异质性,故不能进行合并分析,因此将主要疗效指标结果用森林图表示。统计结果表明:疏肝法中药复方疗效优于复方维生素B6[OR0.02,95%CI(0.00,0.09)]及逍遥丸[OR0.19,95%CI(0.08,0.45)]和逍遥冲剂[OR0.34,95%CI(0.16,0.69)]。结论:疏肝法中药复方对PMS有效,安全性较好,临床上可选择性使用,但由于本研究缺乏严格随机对照试验的评价,尚期待高质量的研究提供更多更好的证据。

Objective：To assess the clinical effeciacy and safety for treating premenstrual syndrome（PMS） by smoothing liver therapy.Methods：We searched randomized controlled trials（RCTs） of patients with PMS by smoothing liver therapy in medical literature databases from establishment to December in 2008.The studies quality were evaluated and meta-analysis was performed by RevMan5.0 software.Results：Geting 16 articles of clinical research five RCTs involving 1171 patients were included.Meta-analysis was not carried out because of apparent clinical heterogeneity.Therefore,the total effective rate was expressed by forest grap.Statistical results show that the effects of smoothing liver therapy were better than compound vitamin B6[OR 0.02,95%CI（0.00,0.09）] and XiaoYao pills[OR 0.19,95%CI（0.08,0.45）] and XiaoYao granules[OR 0.34,95%CI（0.16,0.69）].Conclusion：Smoothing liver therapy have effective in treating PMS with fewer adverse effects.We will have definite selectivity in clinic.The evidence is not strong enough because of low quality of the included studies.Therefore,more high quality RCTs are required.