黏膜疫苗传递系统的研究进展

Progress of Mucosal Vaccine Delivery Systems

黏膜疫苗能同时诱导系统和局部黏膜免疫应答,是预防感染性疾病最理想的一类疫苗。但黏膜疫苗存在两大障碍:抗原无效摄取和难以引发有效免疫反应。因此,研发新型黏膜疫苗传递系统必须要克服这些障碍。本文综述了黏膜免疫的作用机制、黏膜疫苗的特点及其传递系统的研究现状。

Mucosal vaccine is considered as the most suitable type of vaccination agents to combat infectious diseases because of their ability to induce both systemic and local mucosal immune response.However,mucosal vaccines suffer from two main problems：inefficient antigen uptake from the mucosal surfaces and difficulty in eliciting effective immune responses.Therefore,developing new delivery systems for mucosal vaccines must overcome these obstacles. The progress of the mechanism of mucosal immunity,features of mucosal vaccines,and current situation in research of their delivery systems are summarized.