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在液-液两相溶剂中合成邻硝基酚类化合物

Synthesis of o-Nitrophenols in Liquid-Liquid Biphasic System
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摘要 采用平行合成法,以硝酸为硝化试剂,在两相溶剂体系中对六种取代苯酚进行硝化,制得对应的邻硝基苯酚,其结构经1H NMR和MS确证。考察了溶剂体系和反应温度对硝化反应的影响,结果显示在CH2Cl2/H2O或Et2O/H2O组成的两相溶剂体系中于25℃～40℃反应,硝化反应具有良好的位置选择性,并且收率较高。 o-Nitrophenols（2a～2f） were prepared by nitration of six substituted phenols using HNO3 as a nitration reagent in liquid-liquid biphasic system by a parallel synthetic method.The structures were confirmed by 1HNMR and MS.The effect of reaction temperature and solvent system on the nitration were investigated.The results showed that the nitration exhibited good regioselectivity and yields in CH2Cl2/H2O or Et2O/H2O at 25℃～40 ℃.
作者 乌兰辉 杨慧 童元峰 张裴 王冬梅 吴松
机构地区 内蒙古医学院药学院 中国医学科学院北京协和医学院药物研究所卫生部天然合成药物重点实验室
出处 《合成化学》 CAS CSCD 北大核心 2011年第1期99-101,共3页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金青年科学基金资助项目(30901841) 国家创新药物重大专项基金资助项目(2009ZX09301-003-12-1) "重大新药创制"科技重大专项基金资助项目(2009ZX09501)
关键词 邻硝基苯酚 液-液两相溶剂 硝化 合成 o-nitrophenol liquid-liquid biphasic system nitration synthesis
分类号 O625.61 [理学—有机化学]
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参考文献11

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合成化学
2011年 第1期

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